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Methylation Capacity Second, NNMT inhibition affects cellular methylation capacity: SAM is required for hundreds of methyltransferase reactions throughout the cell, and NNMT's consumption of SAM can deplete this critical resource, while the SAH produced by NNMT is a potent product inhibitor of many methyltransferases

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In conjunction with its cofactor NADPH, TXNRD (also termed TrxR) catalyzes the disulfide reduction of TXN [50]

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In vitro , the fluorescent signal of HepG2 cell grafted tumors was significantly stronger than that of normal liver organs (Fig