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6.1 Glutathione metabolism: modern view of biosynthetic pathways, NADPH dependence, and relationship to thioredoxin The synthesis of glutathione (GSH) predominantly occurs through the ATP-dependent -glutamyl cycle, beginning with the action of glutamate-cysteine ligase (GCL), the key rate-limiting enzyme composed of two subunits: a catalytic component (GCLC) and a regulatory modifier (GCLM)

Therefore GSH/GSSG ratio is critical indicator of the health of cell

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Adapting bidirectional encoder representations from transformers (BERT) to assess clinical semantic textual similarity: algorithm development and validation study

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Mitochondrial complex I