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Tirzepatide has dose-dependent adverse effects

Additionally, exposure of microglia to extracellular synOs triggers inflammasome activation and disrupts autophagic regulation, potentially impairing immune surveillance and exacerbating neuroinflammation [174]

doi: 10.1186/s13578-022-00791-w

CagriSema: Fixed-ratio combination of two separate molecules -- cagrilintide (long- acting amylin analog) and semaglutide (GLP-1 agonist) -- co-administered in a single weekly injection

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