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275 Inflammatory molecular signalling pathways in both the central nervous system and the periphery can affect brain connections and synaptic function by affecting components including microglia, complement factors, cytokines and their receptors, MET receptors, and major histocompatibility complex class I molecules (MHCI) (Fig

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Cell-penetrating peptides in glioma Regarding the impermeability of the BBB and cell membrane to therapeutic macromolecules (of large size and low permeability), the incorporation of CPPs, which increase the crossing of the BBB and plasma membrane in peptide-based drug delivery systems, can be a clever solution