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People with Digestive Disorders: Conditions like Crohns disease, celiac disease, or those who have undergone weight loss surgery can impair the absorption of B12

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Important caveat: there are no completed human clinical trials of 5-Amino-1MQ

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The synthesis constitutes a formal total synthesis, since the research groups only prepared the known intermediate cobyric acid, whose chemical conversion to vitamin B 12 was previously reported

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