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Digestive Enzymes

In AD models, phospho-tau colocalizes with lipid rafts enriched in polyunsaturated fatty acids, and -6 fatty acids such as arachidonic acid have been shown to promote tau oligomerization (128, 129)

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Vasoactive Intestinal Peptide (VIP) is also used for nerve-related pain and inflammation

183 Indeed, holomycin induces broad spectrum zinc and iron starvation, with striking parallels to that of the antimicrobial protein, calprotectin, providing support for the idea that transition metal-starvation is an evolutionarily conserved weapon to keep microbial predators at bay

Tanaka T, Narazaki M, Kishimoto T