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doi: 10.1016/j.taap.2011.03.001

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Researchers investigating hair follicles, scalp biology, and tissue health often explore peptides that may influence cellular signaling pathways

This phenomenon, sometimes called tolerance or dose creep, is reported anecdotally with tirzepatide, though the clinical trial data does not show significant tolerance development at fixed doses over 72 weeks

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These apparently conflicting findings suggest that interactions along the skinmammary axis are likely modulated by additional factors, such as milking management, environmental hygiene, and host immune status