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Data from clinical observations and preclinical animal models suggest a step-wise process leading to autoimmune RA 17

10.1038/364626a0 187 ListB

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In addition, chemical treatment (such as p-nitrobenzyl chloride, iodomethane) decreases GSH content in guard cells, in turn, increases the ROS accumulation significantly and thereby enhances guard cell sensitivity to ABA signaling (Okuma et al

A phase 2, Double-Blind, Placebo-Controlled, randomized study of fresolimumab in patients with Steroid-Resistant primary focal segmental glomerulosclerosis