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Duplication publications and reports that were considered either not to be of sufficient scientific rigor (e.g., single case reports) or containing information with little relevance to clinicians were excluded, the latter in order to keep the article of readable size

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Abstract Exposure to tobacco smoke has been associated with harmful effects on child health

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In a study of mainstream smoke from 1R4F cigarettes (two-second puff, one puff per minute, 35-mL puff), male Sprague-Dawley rats had nose-only exposure for four weeks before and during mating and female rats had nose-only exposure for two weeks before mating, during mating, and through gestation day 20 (Carmines et al

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