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NOTES: Honeycomb, Beeswax, Sweet Clover, Patchouli, Crushed Cinnamon, Tobacco Leaves, Olibanum, Honey Syrup, Tonka Beans, Sandalwood, Madagascar Vanilla, Amber, Labdanum, Benzoin, & Honey Whiskey

Between 1988 and 2010, the adult smoking rate in California fell from 22.7 percent to 11.9 percent

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Figure 5C shows that methylation at cg03345232 shared a genetic causal variant, rs12881206, with a 99.7% posterior probability of H4 (PPH4) with QT GWAS signaling

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Over one million cigarette smokers have already switched to IQOS since its initial pilot launch in Nagoya, Japan and Milan, Italy in 2014