While side effects are uncommon, some individuals may experience mild reactions such as irritation or a tingling sensation at the application site
Vitamin D deficiency has been associated with decreased muscle size, and supplementation with vitamin D has effectively improved muscle size and strength in people with deficiencies
Irritation is uncommon but possible
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Excessive intracellular levels of iron ions generate hydroxyl radicals through the Fenton reaction interacting with hydrogen peroxide, thus promoting the production of reactive oxygen species (ROS), which cause lipid peroxidation and are believed to be the primary driver of ferroptotic cell death (Su et al., 2019), and this peroxidative damage can be further exacerbated by reductions in the activity of glutathione peroxidase 4 (GPX4) and glutathione (GSH) together with enhanced malondialdehyde (MDA) activity (Conrad and Sato, 2012
Bosi S, Rauti R, Laishram J, Turco A, Lonardoni D, Nieus T, Prato M, Scaini D, Ballerini L