The combination limited and variable BBB transport plus rapid plasma degradation means peripherally administered DSIP delivers a brief and structurally heterogeneous exposure to the central nervous system, complicating dose-response interpretation in any whole-animal experiment
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The application of anti-cholinergic agents (scopolamine, atropine, 10 mg/kg b.w., i.p.) led to a significant cognitive deficit in the rats, a finding successfully reproduced assessing the animals behavior in water T-maze for a prolonged period
Especially relevant for teams working on: GLP-1 manufacturing Complex peptide purification Synthetic Oligonucleotides Sustainable downstream processing Continuous bioprocessing scale-up YMC ChromaCon YMC Europe GmbH YMC America YMC India Pvt
