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SARS-CoV-2s evolutionary rate has been estimated to be around 910 4 substitutions per site per year [8], while also having a high transmissibility, large portion of asymptomatic cases [9], large pool of susceptible hosts to replicate in [10, 11], and on-going environmental pressures (e.g., low vaccination rates and changes in policies allowing human carriers to continue to transmit the virus), which have allowed SARS-CoV-2 to accumulate mutation in its genome

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doi: 10.1016/j.watres.2007.07.048, 30