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In some embodiments, auris formulations or compositions described herein are controlled release formulations, and are administered at reduced dosing frequency compared to the current standard of care

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Aranda-Martnez P, Fernndez-Martnez J, Ramrez-Casas Y, Rodrguez-Santana C, Rusanova I, Escames G, Acua-Castroviejo D (2023) Chronodisruption and loss of melatonin rhythm, associated with alterations in daily motor activity and mitochondrial dynamics in Parkinsonian Zebrafish, are corrected by melatonin treatment

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Vitamin B1 (Thiamine) Thiamine (vitamin B1) is essential for converting carbohydrates into energy in the brain and body