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Conversely, chronic disease states such as hypertension or hyperglycemia generate reactive oxygen species that further exacerbate mitochondrial damage, creating a self-perpetuating cycle

What is failing is not necessarily the peptide sequence itself, but the system

One of its main jobs is to help regulate blood pressure by counteracting the effects of sodium in the body ( Potassium helps excrete excess sodium through urine

Wang H, Chen Y, Zhai N, Chen X, Gan F, Li H, et al