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doi: 10.1007/s10067-014-2517-2 PMCID: PMC3962576 The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain Jarred Younger, Luke Parkitny, and David McLain Curr Rheumatol Rev

The CagriSema metabolic preservation mechanism, specifically the maintenance of mitochondrial function in skeletal muscle during weight loss, could theoretically slow the rate of weight regain by preventing some of the metabolic adaptation that makes regain almost inevitable