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Not because they're unsafe, but because the weight loss magnitude in controlled trials wasn't commercially viable compared to GLP-1 agonists or other obesity drugs

Proton pump inhibitors and similar medications that lower stomach acid might decrease the absorption of vitamin B12 from food, but this is less of a concern when receiving B12 injections because they bypass the digestive system entirely

A bottle of bacteriostatic water beside it

A thorough medical evaluation is required before prescribing to ensure safety.

This bypasses the need for absorption in the digestive tract, and it ensures that an adequate amount of vitamin B12 reaches the bloodstream

For severe cases, high-dose injections are recommended