These studies are encouraging but cannot be directly translated to women or humans in general
Commonly used in non-clinical research to track changes in tissue-response markers, barrier integrity, and signaling readouts over time (in-vitro and animal models)
In adipocytes, this produces a 1.2 to 1.6-fold increase in intracellular NAD+ Lipogenesis suppression : Increased NAD+ availability in adipocytes suppresses lipogenic pathways, reducing fat synthesis and storage SAM/SAH ratio modulation : Inhibiting NNMT's consumption of SAM alters the SAM/S-adenosylhomocysteine (SAH) ratio, which may affect broader methylation dynamics Muscle effects : In aged mice, NNMT inhibition improved muscle proteome and metabolome profiles through mechanisms distinct from exercise, suggesting direct effects on muscle cell biology How 5-Amino-1MQ Differs from NAD+ Precursors# These approaches are mechanistically complementary, though their combination has not been studied
He was also an MD by the way
84 GuoK.LuJ.HuangY.WuM.ZhangL.YuH.et al (2015)
NAD+ & cellular energy Explored in research on the NNMT pathway for its influence on NAD+ salvage and cellular energy metabolism, in preclinical work
