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In both humans and rodents, variants generated by splicing of exons 4 and exon 6 are referred to as IGF-1Ea while those that contain exons 4, 5, and 6 are designated as IGF-1Eb in rodents and IGF-1Ec in humans (Rotwein et al., 1986
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Physiology of Hyperuricemia and Urate-Lowering Treatments
Int J Neuropsychopharmacol 22(1):5770 Zhang N (2018) Role of methionine on epigenetic modification of DNA methylation and gene expression in animals
Specifically, i) in hepatocytes, while mtROS-activated PERK signaling promotes arsenite-induced ferroptosis by downregulating Mfn-2 and impairing MAMs function, its cleaved C-terminal fragment paradoxically exerts protective effects against alcoholic hepatocyte ferroptosis (75)
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