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Neuronal death is due to the aggregation of ubiquitinated -synuclein, a well-known pathophysiological marker of PD

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Sepesi B, Cuentes EP, Canales JR, Behrens C, Correa A, Antonoff M, Gibbons DL, Heymach J, Hofstetter W, Mehran R, Rice DC , Roth J, Vaporciyan AA, Walsh G, Weissferdt A, Kalhor N, Moran C, Swisher SG, Wistuba I

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In a typical pull-down assay, the process involves three steps: 1