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Lastly, a wide range of soluble factors [e.g., BDNF and chemokine (C-X-C motif) ligand 1 (CXCL1)] released by astrocytes can have myriad effects on myelination, as found in rodents (Tsai et al., 2002

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However, individual responses can vary significantly based on numerous factors including dosage, frequency of administration, and individual biological factors

Stimulation of collagen synthesis in fibroblast cultures by the tripeptide copper complex glycyl L histidyl L lysine Cu2+