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Reconstitute with sterile bacteriostatic water or research-grade solvent

2 Materials and methods 2.1 Protocol and registration This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (Moher et al., 2009) and the guidelines from the Cochrane Handbook for Systematic Reviews of Interventions (Higgins and Green, 2008)

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However, therapeutic doses for treating deficiency and associated nerve damage are substantially higher