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479 Another cascade linking astrocytes to the pathophysiology of Down syndrome is an increased production of hydrogen sulphide, which is catalysed by cystathionine--synthase expressed, more or less exclusively, in astrocytes, and upregulated in a rat model of the disease

5 Conclusions In these studies, within the limitations of small sample sizes, no clinically relevant differences were observed in cagrilintide pharmacokinetics in people with renal or hepatic impairment compared with those with normal function