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Preexisting heterogeneity of inducible nitric oxide synthase expression drives differential growth of Mycobacterium tuberculosis in macrophages

Poor risk factor control translated into clinical outcomes: high polygenic risk was associated with a 21% increase in recurrent stroke (OR 1.21, 95% CI 0.99-1.48), 58% increase in myocardial infarction (OR 1.58,95% CI 1.13-2.23), 31% increase in death (OR 1.31,95% CI 1.07-1.60)

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Phosphorylated -catenin translocates to the nucleus, binds to TCF/LEF transcription factors, and promotes the expression of many target genes, including those involved in cell proliferation, anti-apoptosis, invasion, and angiogenesis (Fig

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