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After that, 60 g of protein was mixed with sampling buffer and resolved on 7.5% SDSpolyacrylamide gel electrophoresis (PAGE)

Activation of cyclic AMP-dependent protein kinase inhibits the desensitization and internalization of metabotropic glutamate receptors 1a and 1b

JAMA Neurology, 70(7), 883890

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Moreover, hyperinsulinemia, a phenomenon associated with insulin resistance, results in high levels of insulin and glucose in blood, leading to an increase in the release of proinflammatory cytokines, promoting microglial proliferation and proinflammatory polarization in vivo (Yang et al., 2022)