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A 2023 study found that combining GHK-Cu with low-molecular-weight hyaluronic acid synergistically upregulated collagen IV by more than 25-fold in fibroblast models and doubled expression in skin underscoring how topical peptides can maintain firmness and repair after systemic cycles ( Jiang et al., 2023, J Cosmet Dermatol )

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Several flavonoids have been reported exhibit pharmacological effects in alleviating itch-associated inflammatory responses in AD models

Trends Biochem Sci 38:592602 Keszler A, Zhang Y, Hogg N (2010) Reaction between nitric oxide, glutathione, and oxygen in the presence and absence of protein: how are S-nitrosothiols formed