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Unlike genetic resistance, these phenotypes enable fungal cells to survive high concentrations of antifungals without a measurable increase in minimum inhibitory concentration (MIC), contributing to chronic and relapsing infections ( Cryptococcus can enter a quiescent state that confers high tolerance to AmB (Ke et al., 2024)

Low glutathione levels send signals that trigger cell death (apoptosis)

Appetite, pp 171179

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This can be exacerbated by high toxin levels