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human efficacy data is extremely limited

Furthermore, H&E-stained slices were used to assess acute tubular injury in a blinded way, including tubular epithelial vacuolization, dilation of tubular lumen, brush border loss, or cast formation

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Hydrogen sulfide targets EGFR cys797/cys798 residues to induce Na + /K + -ATPase endocytosis and inhibition in renal tubular epithelial cells and increase sodium excretion in chronic salt-loaded rats

Nat Immunol (2010) 11(9):78597