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Caracci MO, Avila ME, Espinoza-Cavieres FA, Lopez HR, Ugarte GD, De Ferrari GV
In addition, Fe 2+ is a cofactor of lipoxygenases (LOXs) that catalyzes PUFA-containing phospholipids into pro-ferroptotic lipid peroxidation (Yang et al., 2016)
Su LJ, Zhang JH, Gomez H, Murugan R, Hong X, Xu D, Jiang F, Peng ZY
Oxyhemoglobin suffers autoxidation daily (23%), with oxidation of heme ferrous iron into ferric iron [10], leading to the formation of methemoglobin (metHb), which is not capable of O 2 transport, and the release of superoxide anion that is converted to H 2 O 2 , with a lower oxidant capacity [11]
Differential role of superoxide and glutathione in S-nitrosoglutathione-mediated apoptosis: a rationale for mild forms of familial amyotrophic lateral sclerosis associated with less active Cu,Zn superoxide dismutase mutants