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Health benefits and anti-inflammatory activities have been attributed to the activity of tocochromanol catabolites, especially the 13'-COOH catabolite since it inhibits 5-lipoxygenase a key enzyme in the biosynthesis of leukotrienes from arachidonic acid

However, further dose-response analysis and adjustment for intake of other vitamin and mineral supplements indicated that all-cause mortality risk was significantly increased by 7% only at a dose of 2,000 IU/day, which is notably higher than the UL for adults (1,100 IU/day of synthetic tocopherol or 1,500 IU/day of natural tocopherol)

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For those battling fatigue and sluggishness, IV therapy with glutathione may offer an effective solution

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