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doi: 10.5114/ada.2021.107098 166

Liang L, Shuai R, Yu Y, Qiu W, Shen L, Wu S, Wei H, Chen Y, Yang C, Xu P, Chen X, Zou H, Feng J, Niu T, Hu H, Ye J, Zhang H, Lu D, Gong Z, Zhan X, Ji W, Yu Y, Gu X, Han L

In lesional skin, excessive accumulation of ROS compromises the epidermal barrier, facilitates TEWL and allergen penetration, activates pro-inflammatory signaling cascades, and disrupts immune homeostasis (Raimondo et al., 2023)

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Glutamate plays a central role in regulating mood and cognitive pathways, and has been strongly implicated in mood disorders, aging and neurodegenerative disease