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This is a limitation of our study, and the mechanism by which topical GSSG whitens skin effectively will have to be revealed by further studies

however, hematological toxicities, such as thrombocytopenia, were observed (88)

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As oxidative stress increases, further stimulation of pro-inflammatory cytokines such as TNF- and IL-1 increases and contributes to synaptic dysfunction and neuronal degeneration ( These studies suggest that the loss of antioxidant defense is an early biochemical event rather than a late-stage consequence of neuronal death