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Whether they could better be achieved through other means is, also, beside the point

Tar, a residue present in tobacco smoke, was found to contain at least a dozen carcinogens

The loss-to-follow-up rates were 2.3%, 3.1%, 4.0%, and 6.6% at each time point, respectively, as shown in Figure 1

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The trick is to intensify the buzz without inducing nausea