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Limitations of the Current Evidence Any honest treatment of this topic has to foreground its own limitations, because the strength of the conclusions is bounded by the weakness of the underlying data

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[1] [4] The medication is administered as a once-weekly subcutaneous injection, with dosing typically initiated at 2.5 mg once weekly for 4 weeks, then increased by 2.5 mg every 4 weeks as needed and tolerated up to 15 mg