Timeframe Weeks 4-6 Commonly tracked Tendon and ligament endpoints in animal models Notes Rodent tendon papers commonly assess at this window
Serum IGF-1 levels remained unchanged, confirming the peptide does not activate growth-promoting pathways
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In situations where the FOXO4 protein is bound to p53, there is a tentative observation that p53 is prevented from binding to DNA, inhibiting the process of apoptosis and allowing cells to avoid programmed death
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Collectively, these pathways may be responsible for the novel balance (of gene expression) achieved and ultimately, maintained