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Cutting-edge approaches such as the use of adjuvants (e.g., hyaluronic acid-based and chemical penetration enhancers), bioactive peptides with diverse functionalities, and mechanical force techniquesincluding iontophoresis, microneedles, and electroporationare thoroughly explored

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Since then, knowledge of the above functions of bilirubin has continuously stimulated research, including the evaluation of the clinical significance of serum bilirubin concentrations that are within or moderately above the valid reference interval (RI) of 3-20 mol/L ( 12 )

The volume of work is moderate, not large

These findings underscore the versatility, safety, and therapeutic potential of electroporation for a wide range of medical applications, particularly in cancer treatments and transdermal delivery systems

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