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At the end of the experiment, the food intake had decreased by about 20% in all three groups of tumor-bearing mice, which showed that low- or high-dose L-carnitine treatment did not improve the anorexia associated with cachexia

Additionally, TB-500 has been found to exhibit immunomodulatory effects by preventing apoptosis through cytochrome c release inhibition and modulation of BCL-2 expression and caspase activation [10]

On this basis, we posit that the therapeutic action of Erastin in EMS is critically mediated by these ROS-driven programs, and that pharmacologic suppression of mitophagy may further sensitize lesions to Erastin

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