Richie et al
Y Ruan: conceptualization, supervision, funding acquisition, validation, investigation, visualization, project administration, and writingreview and editing
For instance, activating mutations in KRAS or BRAF markedly reduce the efficacy of EGFR inhibitors, illustrating the limitations of current approaches in addressing the molecular complexity of CRC [4]
Mechanistically, Hedgehog binding to the transmembrane protein patched (PTC) induces the activation of smoothened (SMO), which stimulates the expression of downstream genes such as Ccnd1 via zinc finger transcription (GLI) factors
2000 doi: 10.1164/ajrccm.161.6.9907112
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