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In March 2011, the FDA placed the trial on clinical hold due to GMP compliance issues at the contract manufacturer not safety concerns with RGN-352 itself

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It is made up of three amino acidscysteine, glycine, and glutamic acidand plays a central role in neutralising free radicals, detoxifying cells, and regulating melanin production

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Limited data suggest that GSH and its related enzymes enhance drug resistance, varying with the characteristics of the tumor and the chemotherapy chosen

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