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Indications for Use Clozapine is primarily indicated for: Treatment-resistant schizophrenia (defined as failure of at least two antipsychotics , including one second-generation agent) Reduction of recurrent suicidal behaviour in schizophrenia or schizoaffective disorder Patients intolerant to other antipsychotics, particularly due to extrapyramidal side effects (EPSE) Due to its safety profile, clozapine is reserved for patients who have not responded adequately to standard therapy