Feng R, Rampon C, Tang YP, Shrom D, Jin J, Kyin M, et al
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Subsequent chemical modifications, which were designed to increase hydrophobicity and decrease hydrogen bonding, yielded an orally active, blood-barrier permeant, metabolically stabilized analog, N -hexanoic-Tyr-Ile-(6) aminohexanoic amide (dihexa), that exhibits excellent antidementia activity in the scopolamine and aged rat models and marked synaptogenic activity
TB-500 and BPC-157 are studied for distinct but potentially complementary mechanisms relevant to tissue-repair pathway research: TB-500 for actin-binding and cell migration signalling, and BPC-157 for cytoprotective and angiogenic pathway modulation