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To further examine the role of the signal peptide in PLA2G2F expression, we generated two constructs with mutations in the signal peptide: PLA2G2F(L53V57) (SP_), which has a shorter ER transmembrane H region of the peptide and is predicted to fail ER targeting, and PLA2G2F(A61Y/G63Y) (SP_YY), which harbors substitutions of two residues at the predicted cleavage site of the signal peptide 37
10.1152/ajpcell.00006.2015 Am
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Mumford, S
Dioscin, a natural steroidal saponin metabolite found in various herbs, including Dioscorea bulbifera L
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